抄録
Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 267-269 |
| ページ数 | 3 |
| ジャーナル | Pediatrics International |
| 巻 | 43 |
| 号 | 3 |
| DOI | |
| 出版ステータス | Published - 2001 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 小児科学、周産期医学および子どもの健康