TY - JOUR
T1 - Two-generation reproductive toxicity study of aluminium sulfate in rats
AU - Hirata-Koizumi, Mutsuko
AU - Fujii, Sakiko
AU - Ono, Atsushi
AU - Hirose, Akihiko
AU - Imai, Toshio
AU - Ogawa, Kumiko
AU - Ema, Makoto
AU - Nishikawa, Akiyoshi
N1 - Funding Information:
This study was supported by the Ministry of Health, Labour and Welfare, Japan.
PY - 2011/2
Y1 - 2011/2
N2 - In a two-generation reproductive toxicity study, male and female rats were given aluminium sulfate (AS) in drinking water at 0, 120, 600 or 3000. ppm. AS reduced water consumption in all treatment groups, and body weight was transiently decreased in the 3000. ppm group. In the F1 and F2 pups, preweaning body weight gain was inhibited at 3000. ppm, and the liver and spleen weight was decreased at weaning. At this dose, vaginal opening was slightly delayed. There were no compound-related changes in other reproductive/developmental parameters, including developmental neurobehavioral endpoints. The data indicated that the NOAEL of AS in this two-generation study is 600. ppm for parental systemic toxicity and reproductive/developmental toxicity. The total ingested dose of aluminium from drinking water and food (standard rat diet, containing 25-29. ppm of aluminium) combined for this 600. ppm group was calculated to be 8.06. mg Al/kg bw/day.
AB - In a two-generation reproductive toxicity study, male and female rats were given aluminium sulfate (AS) in drinking water at 0, 120, 600 or 3000. ppm. AS reduced water consumption in all treatment groups, and body weight was transiently decreased in the 3000. ppm group. In the F1 and F2 pups, preweaning body weight gain was inhibited at 3000. ppm, and the liver and spleen weight was decreased at weaning. At this dose, vaginal opening was slightly delayed. There were no compound-related changes in other reproductive/developmental parameters, including developmental neurobehavioral endpoints. The data indicated that the NOAEL of AS in this two-generation study is 600. ppm for parental systemic toxicity and reproductive/developmental toxicity. The total ingested dose of aluminium from drinking water and food (standard rat diet, containing 25-29. ppm of aluminium) combined for this 600. ppm group was calculated to be 8.06. mg Al/kg bw/day.
KW - Aluminium sulfate
KW - Developmental toxicity
KW - Flocculant for water treatment
KW - Food additive
KW - Rat
KW - Two-generation reproductive toxicity
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U2 - 10.1016/j.reprotox.2010.11.004
DO - 10.1016/j.reprotox.2010.11.004
M3 - Article
C2 - 21094250
AN - SCOPUS:79952103587
SN - 0890-6238
VL - 31
SP - 219
EP - 230
JO - Reproductigve Toxicoloy
JF - Reproductigve Toxicoloy
IS - 2
ER -