tRNA modifications and islet function

Fan Yan Wei, Kazuhito Tomizawa

    研究成果査読

    11 被引用数 (Scopus)

    抄録

    Efficient and accurate protein translation is essential to producing insulin in pancreatic β-cells. Transfer RNA (tRNA) is known as the key component of the protein translational machinery. Interestingly, tRNA contains a wide variety of chemical modifications, which are posttranscriptionally catalysed by tRNA modifying enzymes. Recent advances in genome-sequencing technology have unveiled a number of genetic variations that are associated with the development of type 2 diabetes (T2D). Some of these mutations are located in the genes of tRNA modifying enzymes. Using cellular and animal models, it has been showed that dysregulation of tRNA modification impairs protein translation in pancreatic β-cells and leads to aberrant insulin production. In this review, we discuss the recent findings in the molecular functions of tRNA modifications and their involvement in the development of T2D.

    本文言語English
    ページ(範囲)20-27
    ページ数8
    ジャーナルDiabetes, Obesity and Metabolism
    20
    DOI
    出版ステータスPublished - 9月 2018

    ASJC Scopus subject areas

    • 内科学
    • 内分泌学、糖尿病および代謝内科学
    • 内分泌学

    フィンガープリント

    「tRNA modifications and islet function」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル