Total synthesis of two possible diastereomers of (+)-sarcophytonolide C and its structural elucidation

Hiroyoshi Takamura; Kohei Iwamoto; Eiji Nakao; Isao Kadota

doi:10.1021/ol400157s

Total synthesis of two possible diastereomers of (+)-sarcophytonolide C and its structural elucidation

Hiroyoshi Takamura, Kohei Iwamoto, Eiji Nakao, Isao Kadota

研究成果 › 査読

14 被引用数 (Scopus)

抄録

Stereoselective and parallel total syntheses of two possible diastereomers of (+)-sarcophytonolide C have been accomplished. Macrolactonization and transannular ring-closing metathesis (RCM) were the key transformations. Detailed comparisons of their ¹H and ¹³C NMR data and specific rotation with those of the natural product allowed the absolute configuration of (+)-sarcophytonolide C to be determined.

本文言語	English
ページ（範囲）	1108-1111
ページ数	4
ジャーナル	Organic Letters
巻	15
号	5
DOI	https://doi.org/10.1021/ol400157s
出版ステータス	Published - 3月 2013

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/ol400157s

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AU - Kadota, Isao

PY - 2013/3

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AB - Stereoselective and parallel total syntheses of two possible diastereomers of (+)-sarcophytonolide C have been accomplished. Macrolactonization and transannular ring-closing metathesis (RCM) were the key transformations. Detailed comparisons of their 1H and 13C NMR data and specific rotation with those of the natural product allowed the absolute configuration of (+)-sarcophytonolide C to be determined.

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Total synthesis of two possible diastereomers of (+)-sarcophytonolide C and its structural elucidation

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