Total Synthesis of Clavilactone B: A Radical Cyclization-Fragmentation Strategy

Hiroshi Suizu; Daisuke Shigeoka; Hiroshi Aoyama; Takehiko Yoshimitsu

doi:10.1021/ol503356m

Total Synthesis of Clavilactone B: A Radical Cyclization-Fragmentation Strategy

Hiroshi Suizu, Daisuke Shigeoka, Hiroshi Aoyama, Takehiko Yoshimitsu

研究成果 › 査読

19 被引用数 (Scopus)

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A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.

本文言語	English
ページ（範囲）	126-129
ページ数	4
ジャーナル	Organic Letters
巻	17
号	1
DOI	https://doi.org/10.1021/ol503356m
出版ステータス	Published - 1月 2 2015
外部発表	はい

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/ol503356m

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abstract = "A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.",

author = "Hiroshi Suizu and Daisuke Shigeoka and Hiroshi Aoyama and Takehiko Yoshimitsu",

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AU - Yoshimitsu, Takehiko

PY - 2015/1/2

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N2 - A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.

AB - A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.

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Total Synthesis of Clavilactone B: A Radical Cyclization-Fragmentation Strategy

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