TY - JOUR
T1 - Total synthesis and biological evaluation of auripyrones A and B
AU - Hayakawa, Ichiro
AU - Takemura, Takuma
AU - Fukasawa, Emi
AU - Ebihara, Yuta
AU - Sato, Natsuki
AU - Nakamura, Takayasu
AU - Suenaga, Kiyotake
AU - Kigoshi, Hideo
PY - 2012
Y1 - 2012
N2 - The total synthesis of auripyrones was achieved by using a novel aldol-type reaction of γ-pyrone as a key step. From this synthetic work, we have established the stereostructure and absolute configuration of auripyrone B. Furthermore, the cytotoxicities of auripyrones against a panel of 39 human cancer cell lines (termed JFCR39) at the Japanese Foundation for Cancer Research were investigated. The patterns of the differential cytotoxicities of auripyrones were COMPARE negative, suggesting that they inhibit cancer cell proliferation through a novel mechanism.
AB - The total synthesis of auripyrones was achieved by using a novel aldol-type reaction of γ-pyrone as a key step. From this synthetic work, we have established the stereostructure and absolute configuration of auripyrone B. Furthermore, the cytotoxicities of auripyrones against a panel of 39 human cancer cell lines (termed JFCR39) at the Japanese Foundation for Cancer Research were investigated. The patterns of the differential cytotoxicities of auripyrones were COMPARE negative, suggesting that they inhibit cancer cell proliferation through a novel mechanism.
UR - http://www.scopus.com/inward/record.url?scp=84867797961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867797961&partnerID=8YFLogxK
U2 - 10.1246/bcsj.20120162
DO - 10.1246/bcsj.20120162
M3 - Article
AN - SCOPUS:84867797961
SN - 0009-2673
VL - 85
SP - 1077
EP - 1092
JO - Bulletin of the Chemical Society of Japan
JF - Bulletin of the Chemical Society of Japan
IS - 10
ER -
