@article{1dc751052e134916a6fa733fea994a1e,
title = "The first case of chronic inflammatory demyelinating polyneuropathy after transsexualism and continuous testosterone administration",
abstract = "We report on a 35-year-old man who had gender dysphoria following unilateral ovariectomy and then received continuous testosterone injection for nine years, inducing chronic inflammatory demyelinating polyneuropathy (CIDP). He developed recurrent muscle weakness and numbness in the extremities and displayed demyelinating neuropathy, detected by nerve conduction studies and a sural nerve biopsy. Repeated intravenous immunoglobulin (IVIg) therapy and the administration of oral prednisolone improved symptoms and inhibited their recurrence. A relatively high level of serum testosterone as a genetic female might have caused the neurotoxicity of the peripheral nerve, leading to CIDP.",
keywords = "chronic inflammatory demyelinating polyneuropathy, gender dysphoria, IVIg, testosterone",
author = "Yuki Taira and Yosio Omote and Yuko Kawahara and Emi Nomura and Ryo Sasaki and Namiko Matsumoto and Chika Matsuoka and Mami Takemoto and Ryuta Morihara and Nozomi Hishikawa and Toru Yamashita and Koji Abe",
note = "Funding Information: We appreciate the patient's cooperation. This work was partly supported by a Grant‐in‐Aid for Scientific Research ((B) 17H0419611, (C) 17H0975609, and 17K1082709) and by Grants‐in‐Aid from the Research Committees (Kaji R, Toba K, and Tsuji S) from the Japan Agency for Medical Research and Development (7211700121, 7211800049, and 7211800130). We are grateful to Dr Kusunoki of the Department of Neurology, Faculty of Medicine, Kindai University, for his assistance with the anti‐ganglioside antibody assay. We are grateful to Dr Maruyama of the Department of Preventive Dentistry at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences for his technical assistance with the OXY‐Adsorbent and d‐ROMs tests. Publisher Copyright: {\textcopyright} 2021 Societas Neurologica Japonica (Japanese Society of Neurology) and John Wiley & Sons Australia, Ltd.",
year = "2021",
doi = "10.1111/ncn3.12514",
language = "English",
journal = "Neurology and Clinical Neuroscience",
issn = "2049-4173",
publisher = "Wiley-Blackwell Publishing Ltd",
}