@inbook{c52b83ab954e47cdbd9a5cf1f4cb7097,
title = "The Evaluation of Meniscus Regenerative Effects of LIPUS-Induced CCN Proteins: Induction by LIPUS of CCN2 and Meniscus-Related Genes in Cultured Meniscus Cells and Meniscus Tissues",
abstract = "Menisci are a pair of crescent-shaped fibrocartilages and composed primarily of type I collagen. Inner region of the meniscus has similar characteristics to articular cartilage. Low-intensity pulsed ultrasound (LIPUS) has been reported to have chondroprotective effects on chondrocytes by inducing the expression of chondrocyte differentiation markers and CCN2/CTGF production. Here, we describe an experimental approach that investigates the distinct cellular behavior of human inner and outer meniscus cells in response to LIPUS stimulation. Our experimental model can analyze the relationships between LIPUS-induced CCN2 and its repairing role in the meniscus.",
keywords = "CCN2/CTGF, Healing, Low-intensity pulsed ultrasound (LIPUS), Meniscus",
author = "Yusuke Kamatsuki and Eriko Aoyama and Takayuki Furumatsu and Toshifumi Ozaki and Masaharu Takigawa",
note = "Funding Information: We thank Dr. Satoshi Kubota and Dr. Takashi Nishida for their kind assistance. This work was supported by the programs JSPS KAKENHI Grants-in-Aid for (B) #JP19H03817 (to MT) and Challenging Research (Pioneering) #JP20K20611 (to MT) from the Japan Society for the Promotion of Science, Japan. Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2023",
doi = "10.1007/978-1-0716-2744-0_15",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "223--235",
booktitle = "Methods in Molecular Biology",
}