@article{8c3a04aad20546c88f0e6ca8646ff35c,
title = "Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line",
abstract = "Connective tissue growth factor (CTGF) is known to be a multifunctional growth factor that is overexpressed in several types of malignancies. In this study, effects of CTGF gene overexpression on the phenotypes of oral squamous cell carcinoma cells were investigated by using a cell line with undetectable endogenous CTGF expression. Surprisingly, our results indicated that CTGF-overexpressed clones were characterized by attenuated cell growth and less potent tumorigenicity, with coincidental downregulation of prothymosin α gene. Although CTGF is known to promote cell proliferation in mesenchymal cells, our present results suggest that CTGF acts as a negative regulator of the cell growth in oral squamous cell carcinoma possibly through its interaction with growth modifiers inside the cell.",
keywords = "Connective tissue growth factor, Negative regulator, Oral squamous cell carcinoma, Prothymosin alpha",
author = "Moritani, {Norifumi H.} and Satoshi Kubota and Takashi Nishida and Harumi Kawaki and Seiji Kondo and Toshio Sugahara and Masaharu Takigawa",
note = "Funding Information: This work was supported in part by the program Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (S.K., M.T.); grants from the Research for the Future Programme of the Japan Society for the Promotion of Science (Biological Tissue Engineering Project, Contract Grant No. JSPS-RFTF98100201) (M.T.); the Naito Foundation (M.T.); the Nakatomi Health Science Foundation (S.K., M.T.); Ryobi-teien Memorial Foundation (S.K.); the Foundation for Growth Science in Japan (M.T.); and the Sumitomo Foundation (M.T.). The authors wish to thank Drs Hitoshi Nagatsuka, Akira Sasaki, Tohru Nakanishi, Gen Yosimichi, Takanori Eguchi, Eiji Nakata, Kumiko Nawachi, and Toshie Sakamoto for helpful suggestions and discussions, Dr You-Jin Lee and Ms Kazumi for technical assistance; and Ms Yuki Nonami for secretarial assistance.",
year = "2003",
month = mar,
day = "31",
doi = "10.1016/S0304-3835(02)00718-8",
language = "English",
volume = "192",
pages = "205--214",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",
}
