抄録
Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 3883-3897 |
| ページ数 | 15 |
| ジャーナル | Molecules |
| 巻 | 19 |
| 号 | 4 |
| DOI | |
| 出版ステータス | Published - 4月 2014 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 分析化学
- 化学（その他）
- 分子医療
- 薬科学
- 創薬
- 物理化学および理論化学
- 有機化学