@article{4f1965cbb3ba4b2c8af845ef4c6efd78,
title = "Stereodivergent and stereoselective synthesis of cis-and trans-4-substituted prolinols",
abstract = "- Stereoselective synthesis of 4-substituted prolinol derivatives has been developed. Thus, Suzuki-Miyaura cross-coupling of vinyl tritiate provided the common synthetic intermediates toward the stereodivergent synthesis of cis- and ira«s-4-substituted prolinols. These two kinds of target compounds were obtained by diastereoselective hydrogenation of the coupling products with Pd/C and Crabtree catalyst, respectively. In addition, the obtained 4-substituted prolinol was transformed to the corresponding proline derivative via oxidation in one step.",
author = "Junki Ando and Aoi Tazawa and Kohei Ishizawa and Minoru Tanaka and Hiroyoshi Takamura",
note = "Funding Information: We thank Dr. Masayuki Watanabe, Mr. Kazunari Shimooka, and Ms. Kaoru Marukawa for valuable discussions. We also thank Ms. Kaori Murakoshi and Mr. Ryo Sakakibara for technical support of LC-MS/MS analysis, Ms. Saori Tahara for technical support of IR analysis, and Mr. Iwao Takamuro for helpful advice. This research was supported by Mitsubishi Tanabe Pharma Corporation. Publisher Copyright: {\textcopyright} 2019 The Japan Institute of Heterocyclic Chemistry",
year = "2019",
doi = "10.3987/COM-18-S(F)8",
language = "English",
volume = "99",
pages = "188--199",
journal = "Heterocycles",
issn = "0385-5414",
publisher = "Japan Institute of Heterocyclic Chemistry",
number = "1",
}