@article{b540778706e147ca9a8bf8087a62d8c8,
title = "Spastic paraplegia accompanied by extrapyramidal sign and frontal cognitive dysfunction",
abstract = "A complicated form of spastic paraplegia is a neurodegenerative disorder presenting as progressive spasticity in the bilateral lower limbs accompanied by some clinical features. The present case showed spastic paralysis and hyperreflexia in all extremities as well as lead pipe rigidity in the neck and bilateral upper extremities (R < L), decreased scores on frontal cognitive tests, a decreased accumulation of the right dorsal putamen on a DAT scan, and hypoperfusion of the bilateral frontal lobes on 99mTc-ECD single photon emission computed tomography (SPECT). The present case provides a new spectrum of spastic paraplegia based on the evidence of clinical scores and the findings of brain functional imaging.",
keywords = "Extrapyramidal sign, Frontal cognitive dysfunction, Spastic paraplegia",
author = "Ryo Sasaki and Yasuyuki Ohta and Kota Sato and Koh Tadokoro and Yoshiaki Takahashi and Jingwei Shang and Mami Takemoto and Nozomi Hishikawa and Toru Yamashita and Hiroyuki Ishiura and Shoji Tsuji and Koji Abe",
note = "Funding Information: This work was partly supported by a Grant-in-Aid for Scientific Research (B) 17H0419619, (C) 15K0931607, 17H0419619 and 17K1082709, and by Grants-in-Aid from the Research Committees (Kaji R, Toba K, and Tsuji S) from the Japan Agency for Medical Research and Development (AMED) 7211700176, 7211700180 and 7211700095. Publisher Copyright: {\textcopyright} 2019 The Japanese Society of Internal Medicine.",
year = "2019",
doi = "10.2169/internalmedicine.2765-19",
language = "English",
volume = "58",
pages = "3163--3165",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "21",
}