Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling

Ichiro Hayakawa; Mitsuru Ueda; Masashi Yamaura; Yoichi Ikeda; Yuta Suzuki; Kensaku Yoshizato; Hideo Kigoshi

doi:10.1021/ol800554f

Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling

Ichiro Hayakawa, Mitsuru Ueda, Masashi Yamaura, Yoichi Ikeda, Yuta Suzuki, Kensaku Yoshizato, Hideo Kigoshi

研究成果 › 査読

28 被引用数 (Scopus)

抄録

Second-generation total synthesis of haterumalide NA, a potent cytotoxic marine macrolide, was achieved by using B-alkyl Suzuki-Miyaura coupling and Nozaki-Hiyama-Kishi coupling as key steps (1.2% in 33 steps). Compared to our first-generation approach, the second-generation synthesis is much improved in the yield of key intermediate.

本文言語	English
ページ（範囲）	1859-1862
ページ数	4
ジャーナル	Organic Letters
巻	10
号	9
DOI	https://doi.org/10.1021/ol800554f
出版ステータス	Published - 5月 1 2008
外部発表	はい

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1021/ol800554f

他のファイルとリンク

引用スタイル

@article{4d7ac8b70b3b47fc96148eb6d19e9c81,

title = "Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling",

abstract = "Second-generation total synthesis of haterumalide NA, a potent cytotoxic marine macrolide, was achieved by using B-alkyl Suzuki-Miyaura coupling and Nozaki-Hiyama-Kishi coupling as key steps (1.2% in 33 steps). Compared to our first-generation approach, the second-generation synthesis is much improved in the yield of key intermediate.",

author = "Ichiro Hayakawa and Mitsuru Ueda and Masashi Yamaura and Yoichi Ikeda and Yuta Suzuki and Kensaku Yoshizato and Hideo Kigoshi",

year = "2008",

month = may,

day = "1",

doi = "10.1021/ol800554f",

language = "English",

volume = "10",

pages = "1859--1862",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling

AU - Hayakawa, Ichiro

AU - Ueda, Mitsuru

AU - Yamaura, Masashi

AU - Ikeda, Yoichi

AU - Suzuki, Yuta

AU - Yoshizato, Kensaku

AU - Kigoshi, Hideo

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Second-generation total synthesis of haterumalide NA, a potent cytotoxic marine macrolide, was achieved by using B-alkyl Suzuki-Miyaura coupling and Nozaki-Hiyama-Kishi coupling as key steps (1.2% in 33 steps). Compared to our first-generation approach, the second-generation synthesis is much improved in the yield of key intermediate.

AB - Second-generation total synthesis of haterumalide NA, a potent cytotoxic marine macrolide, was achieved by using B-alkyl Suzuki-Miyaura coupling and Nozaki-Hiyama-Kishi coupling as key steps (1.2% in 33 steps). Compared to our first-generation approach, the second-generation synthesis is much improved in the yield of key intermediate.

UR - http://www.scopus.com/inward/record.url?scp=48849096587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48849096587&partnerID=8YFLogxK

U2 - 10.1021/ol800554f

DO - 10.1021/ol800554f

M3 - Article

C2 - 18396895

AN - SCOPUS:48849096587

SN - 1523-7060

VL - 10

SP - 1859

EP - 1862

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling

抄録

ASJC Scopus subject areas

UN SDG

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル