TY - JOUR
T1 - Safety of cold snare polypectomy for duodenal adenomas in familial adenomatous polyposis
T2 - A prospective exploratory study
AU - Hamada, Kenta
AU - Takeuchi, Yoji
AU - Ishikawa, Hideki
AU - Ezoe, Yasumasa
AU - Arao, Masamichi
AU - Suzuki, Sho
AU - Iwatsubo, Taro
AU - Kato, Minoru
AU - Tonai, Yusuke
AU - Shichijo, Satoki
AU - Yamasaki, Yasushi
AU - Matsuura, Noriko
AU - Nakahira, Hiroko
AU - Kanesaka, Takashi
AU - Yamamoto, Sachiko
AU - Akasaka, Tomofumi
AU - Hanaoka, Noboru
AU - Higashino, Koji
AU - Uedo, Noriya
AU - Ishihara, Ryu
AU - Okada, Hiroyuki
AU - Iishi, Hiroyasu
N1 - Funding Information:
The authors thank Ms. Ryoko Yanagida and Ms. Eri Okuda (Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine) for their assistance with data management. We thank Nancy Schatken, BS, MT(ASCP), from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. The study was supported by a grant from the Practical Research for Innovative Cancer Control (16ck0106098h0003) from the Japan Agency for Medical Research and Development (AMED).
Publisher Copyright:
© 2018 All rights reserved.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Background Cold snare polypectomy (CSP) to remove multiple duodenal adenomas (MDAs) in patients with familial adenomatous polyposis (FAP) could be an effective and less invasive method than more extensive surgery. The aim of the present study was to determine the safety of this procedure. Methods This prospective exploratory study included 10 consecutive patients with FAP and MDAs who underwent CSP for as many as 50 duodenal adenomas. The primary outcome was the incidence of severe adverse events. Results 10 patients were enrolled and underwent 332 CSPs from June 2016 to January 2017.?The median procedure time was 33 minutes (range 25?-?53), and the median number of polyps removed during a single session was 35 (range 10?-?50). Most of the removed polyps were?≤?10?mm. None of the 10 patients experienced a severe adverse event. One patient developed arterial bleeding during the procedure, but it was easily managed using hemoclips. Conclusions CSP for MDAs in patients with FAP was safe. The long-term efficacy of this procedure should be investigated.
AB - Background Cold snare polypectomy (CSP) to remove multiple duodenal adenomas (MDAs) in patients with familial adenomatous polyposis (FAP) could be an effective and less invasive method than more extensive surgery. The aim of the present study was to determine the safety of this procedure. Methods This prospective exploratory study included 10 consecutive patients with FAP and MDAs who underwent CSP for as many as 50 duodenal adenomas. The primary outcome was the incidence of severe adverse events. Results 10 patients were enrolled and underwent 332 CSPs from June 2016 to January 2017.?The median procedure time was 33 minutes (range 25?-?53), and the median number of polyps removed during a single session was 35 (range 10?-?50). Most of the removed polyps were?≤?10?mm. None of the 10 patients experienced a severe adverse event. One patient developed arterial bleeding during the procedure, but it was easily managed using hemoclips. Conclusions CSP for MDAs in patients with FAP was safe. The long-term efficacy of this procedure should be investigated.
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U2 - 10.1055/s-0043-124765
DO - 10.1055/s-0043-124765
M3 - Article
C2 - 29351704
AN - SCOPUS:85040798651
SN - 0013-726X
VL - 50
SP - 511
EP - 517
JO - Endoscopy
JF - Endoscopy
IS - 5
ER -