Room-temperature palladium-catalyzed and copper(I)-mediated coupling reactions of acid chlorides with boronic acids under neutral conditions

Yasushi Nishihara; Yoshiaki Inoue; Mamoru Fujisawa; Kentaro Takagi

doi:10.1055/s-2005-872661

Room-temperature palladium-catalyzed and copper(I)-mediated coupling reactions of acid chlorides with boronic acids under neutral conditions

Yasushi Nishihara, Yoshiaki Inoue, Mamoru Fujisawa, Kentaro Takagi

異分野基礎科学研究所

研究成果 › 査読

36 被引用数 (Scopus)

抄録

The palladium-catalyzed cross-coupling reactions of acid chlorides with arylboronic acids in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator under strictly non-basic and mild reaction conditions afford the unsymmetrical ketones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring is compatible.

本文言語	English
ページ（範囲）	2309-2312
ページ数	4
ジャーナル	Synlett
号	15
DOI	https://doi.org/10.1055/s-2005-872661
出版ステータス	Published - 9月 19 2005

ASJC Scopus subject areas

有機化学

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10.1055/s-2005-872661

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AU - Nishihara, Yasushi

AU - Inoue, Yoshiaki

AU - Fujisawa, Mamoru

AU - Takagi, Kentaro

PY - 2005/9/19

Y1 - 2005/9/19

N2 - The palladium-catalyzed cross-coupling reactions of acid chlorides with arylboronic acids in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator under strictly non-basic and mild reaction conditions afford the unsymmetrical ketones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring is compatible.

AB - The palladium-catalyzed cross-coupling reactions of acid chlorides with arylboronic acids in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator under strictly non-basic and mild reaction conditions afford the unsymmetrical ketones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring is compatible.

KW - Boronic acid

KW - Copper

KW - Cross-coupling reaction

KW - Ketones

KW - Palladium

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