Rebamipide suppresses mite-induced asthmatic responses in NC/Nga mice

Ikuo Murakami, Ran Zhang, Masayuki Kubo, Kenjiro Nagaoka, Eri Eguchi, Keiki Ogino


4 被引用数 (Scopus)


Allergic asthma caused by continuous allergen exposure evokes allergenspecific Th2 responses and is characterized by chronic airway infl ammationand hyperresponsiveness. A previous report showed that rebamipide improved asthmatic symptoms in an ovalbumin/trypsin mice model. However, it is still unclear how rebamipide exerts its effects in asthma. In this study, rebamipide improved the asthmatic responses induced by mite exposure in NC/Nga mice, revealing the mechanism of this therapeutic effect. Rebamipide suppressed the infiltration of eosinophils into the airways and lung as well as attenuating the production of reactive oxygen species in tissues. In addition to these anti-inflammatory effects, rebamipide inhibited the production of IL-33, a member of the IL-1 family that drives the subsequent production of Th2-associated cytokines. These observations identify the point where rebamipide exerts its suppressive action on asthma and suggest that rebamipide has therapeutic potential in preventing mite-induced asthma.

ジャーナルAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
出版ステータスPublished - 2015

ASJC Scopus subject areas

  • 生理学
  • 呼吸器内科
  • 生理学(医学)
  • 細胞生物学


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