@article{b4d740287e8e4ea388a3ca4800833374,
title = "Preparation of chitosan-hydroxyapatite composite mono-fiber using coagulation method and their mechanical properties",
abstract = "Autograft has been carried out for anterior cruciate ligament (ACL) reconstruction surgery. However, it has negative aspect because patients lose their healthy ligaments from other part. We focus on a chitosan-hydroxyapatite (HAp) composite fiber as a scaffold of ligament regeneration. Chitosan- HAp composite fiber was made by using coagulation method. Chitosan-NaH2PO4 solution was coagulated with coagulation bath including calcium ion to get the mono-fiber and then treated with sodium hydroxide solution to form HAp in fiber matrix. The mechanical property of the fiber was improved by the stretching of the wet one because of the orientation of chitosan molecule and the interaction between chitosan and HAp. Maximum stress was improved with increasing of sodium dihydrogen phosphate until 0.03 M. The swelling ratio of the fiber was inhibited by composited with HAp. Additionally, bone-bonding ability was confirmed by SBF soaking tests.",
keywords = "Artificial ligament, Chitosan, Coagulation method, Fiber, Hydroxyapatite, Mechanical property",
author = "Takuma Okada and Yuta Nobunaga and Toshiisa Konishi and Tomohiko Yoshioka and Satoshi Hayakawa and Lopes, {Maria Ascens{\~a}o} and Toshiki Miyazaki and Yuki Shirosaki",
note = "Funding Information: A part of this work was supported by ?Promotion and Standardization of the Tenure-Track System (Kojinsenbatu)? from Ministry of Education. Culture, Sports, Science and Technology (MEXT), Japan, Grants-in-Aid for Challenging Exploratory Research (16K12898) from Japan Society of the Promotion of Science, Sasakawa Scientific Research Grant from The Japan Science Society, NIMS microstructural characterization platform (NMCP) as a program of ?Nanotechnology Platform? of MEXT, and Portuguese Foundation for Science and Technology (FCT: UID/EMS/00285/2013). We are grateful Ms. I. Koda in NMCP for preparing TEM samples. Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",
year = "2017",
month = nov,
day = "1",
doi = "10.1016/j.carbpol.2017.07.072",
language = "English",
volume = "175",
pages = "355--360",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Elsevier Limited",
}