Possible involvement of p38 MAP kinase in HSP70 expression induced by hypoxia in rat primary astrocytes

Takashi Uehara, Masayuki Kaneko, Shinji Tanaka, Yasunobu Okuma, Yasuyuki Nomura

研究成果査読

69 被引用数 (Scopus)

抄録

The aim of this study was to elucidate the possible mechanism of HSP induction in response to hypoxia in rat primary astrocytes. Treatment with SB203580, a selective p38 MAP kinase (p38 MAPK) inhibitor, attenuated the increase in HSP70 in a concentration-dependent manner, p38 MAPK was activated in response to hypoxic treatment. These results suggest that p38 MAPK positively regulates hypoxia-induced HSP70 expression in astrocytes.

本文言語English
ページ(範囲)226-230
ページ数5
ジャーナルBrain Research
823
1-2
DOI
出版ステータスPublished - 3月 27 1999
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

フィンガープリント

「Possible involvement of p38 MAP kinase in HSP70 expression induced by hypoxia in rat primary astrocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル