Polycyclic N-heterocyclic compounds. Part 58: Rearrangement reactions of fused 3-(2-bromoethyl)pyrimidin-4(3H)-ones with primary amines and antidepressive evaluation of the products

Hiromi Ohtomo, Tsuyoshi Tagata, Kenji Sasaki, Takashi Hirota, Kensuke Okuda

    研究成果査読

    10 被引用数 (Scopus)

    抄録

    Reaction of fused 3-(2-bromoethyl)pyrimidin-4(3H)-ones with primary alkylamines gave abnormal fused 3-alkyl-4-alkyliminopyrimidines via a new rearrangement, as well as normal substituted 3-(2-alkylaminoethyl) derivatives. Antidepressive evaluation of these compounds was performed by antireserpine action and one compound exhibited the positive activity comparable to imipramine.

    本文言語English
    ページ(範囲)12541-12546
    ページ数6
    ジャーナルTetrahedron
    63
    51
    DOI
    出版ステータスPublished - 12月 17 2007

    ASJC Scopus subject areas

    • 生化学
    • 創薬
    • 有機化学

    フィンガープリント

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