TY - JOUR
T1 - Peripheral artery disease is associated with frailty in chronic hemodialysis patients
AU - Okuyama, Michihiro
AU - Takeuchi, Hidemi
AU - Uchida, Haruhito A.
AU - Kakio, Yuki
AU - Okuyama, Yuka
AU - Umebayashi, Ryoko
AU - Wada, Kentaro
AU - Sugiyama, Hitoshi
AU - Sugimoto, Ken
AU - Rakugi, Hiromi
AU - Kasahara, Shingo
AU - Wada, Jun
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Jun Wada receives speaker honoraria from Astellas, Boehringer Ingelheim, Daiichi Novartis, Sankyo, and Tanabe Mitsubishi, and receives grant support from Astellas, Bayer, Baxter, Chugai, Daiichi Sankyo, Kissei, Kyowa Hakko Kirin, MSD, Novartis, Novo Nordisk, Ono, Otsuka, Pfizer, Teijin, Torii, and Takeda.
Funding Information:
We would like to thank Dr. Taro Sugimoto of the Sugimoto Clinic and Dr. Hiroo Hashimoto from Innoshima General Hospital for their kind help in contacting the patients of their respective institutions, and the medical staff at each institution for their help in collecting the patients? data. We also would like to thank Akiyo Nouchi for her help to manage data.
Publisher Copyright:
© The Author(s) 2018.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Objectives: The clinical condition of frailty is a common problem in the elderly population. However, the relationship between peripheral artery disease and frailty in hemodialysis patients remains unknown. The aim of this study was to identify the relationships between peripheral artery disease and frailty in Japanese chronic hemodialysis patients. Methods: A total of 362 chronic hemodialysis patients who regularly visited six institutions were enrolled. To evaluate frailty, the modified Fried’s frailty phenotype adjusted for Japanese were used. Peripheral artery disease was defined as ankle-brachial index <0.9. Results: Of 362 patients, 62 patients (17.1%) were categorized as peripheral artery disease group and 300 patients (82.9%) as Non-peripheral artery disease group. The prevalence of frailty in the peripheral artery disease group was significantly higher than in the Non-peripheral artery disease group (34% vs. 18%, P = 0.0103). Non-shunt side grip strength was significantly stronger in the Non-peripheral artery disease group (23.6 kg vs. 17.0 kg, P < 0.0001). Thigh circumferences were also significantly larger in the Non-peripheral artery disease group (41.7 cm vs. 39.7 cm, P = 0.0054). A multivariate logistic regression analysis demonstrated that the factors independently associated with peripheral artery disease were as follows: frailty (odds ratio = 2.06, 95% confidence interval 1.09–3.89) and myocardial infarction (odds ratio = 3.74, 95% confidence interval 2.05–6.83). Conclusions: It is concluded that peripheral artery disease is closely associated with frailty in hemodialysis patients.
AB - Objectives: The clinical condition of frailty is a common problem in the elderly population. However, the relationship between peripheral artery disease and frailty in hemodialysis patients remains unknown. The aim of this study was to identify the relationships between peripheral artery disease and frailty in Japanese chronic hemodialysis patients. Methods: A total of 362 chronic hemodialysis patients who regularly visited six institutions were enrolled. To evaluate frailty, the modified Fried’s frailty phenotype adjusted for Japanese were used. Peripheral artery disease was defined as ankle-brachial index <0.9. Results: Of 362 patients, 62 patients (17.1%) were categorized as peripheral artery disease group and 300 patients (82.9%) as Non-peripheral artery disease group. The prevalence of frailty in the peripheral artery disease group was significantly higher than in the Non-peripheral artery disease group (34% vs. 18%, P = 0.0103). Non-shunt side grip strength was significantly stronger in the Non-peripheral artery disease group (23.6 kg vs. 17.0 kg, P < 0.0001). Thigh circumferences were also significantly larger in the Non-peripheral artery disease group (41.7 cm vs. 39.7 cm, P = 0.0054). A multivariate logistic regression analysis demonstrated that the factors independently associated with peripheral artery disease were as follows: frailty (odds ratio = 2.06, 95% confidence interval 1.09–3.89) and myocardial infarction (odds ratio = 3.74, 95% confidence interval 2.05–6.83). Conclusions: It is concluded that peripheral artery disease is closely associated with frailty in hemodialysis patients.
KW - Frailty
KW - hemodialysis
KW - peripheral artery disease
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U2 - 10.1177/1708538118756690
DO - 10.1177/1708538118756690
M3 - Article
C2 - 29402196
AN - SCOPUS:85042122004
SN - 1708-5381
VL - 26
SP - 425
EP - 431
JO - Vascular
JF - Vascular
IS - 4
ER -