Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges agelas sp

Atsushi Araki; Takaaki Kubota; Kazuki Aoyama; Yuzuru Mikami; Jane Fromont; Ju N.Ichi Kobayashi

doi:10.1021/ol900328c

Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges agelas sp

Atsushi Araki, Takaaki Kubota, Kazuki Aoyama, Yuzuru Mikami, Jane Fromont, Ju N.Ichi Kobayashi

研究成果 › 査読

45 被引用数 (Scopus)

抄録

Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated fromSROkinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity.

本文言語	English
ページ（範囲）	1785-1788
ページ数	4
ジャーナル	Organic Letters
巻	11
号	8
DOI	https://doi.org/10.1021/ol900328c
出版ステータス	Published - 4月 16 2009
外部発表	はい

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1021/ol900328c

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AU - Araki, Atsushi

AU - Kubota, Takaaki

AU - Aoyama, Kazuki

AU - Mikami, Yuzuru

AU - Fromont, Jane

AU - Kobayashi, Ju N.Ichi

PY - 2009/4/16

Y1 - 2009/4/16

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AB - Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated fromSROkinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity.

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Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges agelas sp

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ASJC Scopus subject areas

UN SDG

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