TY - JOUR
T1 - Moesin-ezrin-radixin-like protein merlin
T2 - Its conserved and distinct functions from those of ERM proteins
AU - Senju, Yosuke
AU - Hibino, Emi
N1 - Funding Information:
This work was supported by the Okayama Foundation for Science and Technology (Y.S.); ONO Medical Research Foundation (Y.S.); Takeda Science Foundation (Y.S.); Naito Foundation (Y.S.); The Uehara Memorial Foundation (E.H.); and The Foundation for The Promotion of Ion Engineering (E.H.).
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/2
Y1 - 2023/2
N2 - Neurofibromatosis type 2 (NF2), which encodes merlin (moesin-ezrin-radixin-like protein), belongs to the band 4.1, ezrin, radixin, moesin (FERM) domain-containing 4.1 superfamily. Merlin shares sequence homology with ERM proteins, is evolutionarily conserved, and acts as a tumour suppressor. Here, we describe the molecular functions of merlin from a biophysical point of view. We describe the structural basis for merlin regulatory mechanisms based on its interaction with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) along with its interaction partners, and then describe its physiological functions in cell–cell adhesions. Elucidation of these merlin functions will lead to a clear understanding of its fundamental roles in cells and tissues.
AB - Neurofibromatosis type 2 (NF2), which encodes merlin (moesin-ezrin-radixin-like protein), belongs to the band 4.1, ezrin, radixin, moesin (FERM) domain-containing 4.1 superfamily. Merlin shares sequence homology with ERM proteins, is evolutionarily conserved, and acts as a tumour suppressor. Here, we describe the molecular functions of merlin from a biophysical point of view. We describe the structural basis for merlin regulatory mechanisms based on its interaction with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) along with its interaction partners, and then describe its physiological functions in cell–cell adhesions. Elucidation of these merlin functions will lead to a clear understanding of its fundamental roles in cells and tissues.
KW - Cell–cell adhesions
KW - Contact inhibition of proliferation
KW - Epithelial–mesenchymal transition (EMT)
KW - Ezrin-radixin-moesin (ERM)
KW - Merlin (moesin-ezrin-radixin-like protein)
KW - Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P)
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U2 - 10.1016/j.bbamem.2022.184076
DO - 10.1016/j.bbamem.2022.184076
M3 - Article
C2 - 36302494
AN - SCOPUS:85142755963
SN - 0005-2736
VL - 1865
JO - Biochimica et Biophysica Acta - Biomembranes
JF - Biochimica et Biophysica Acta - Biomembranes
IS - 2
M1 - 184076
ER -