Methylenetetrahydrofolate reductase polymorphism in childhood primary focal segmental glomerulosclerosis

Chaochun Zou, Hirokazu Tsukahara, Masahiro Hiraoka, Jiang Mizu, Yukiko Todoroki, Yusei Ohshima, Hideki Kimura, Kazuo Tsuzuki, Mitsufumi Mayumi

研究成果査読

2 被引用数 (Scopus)

抄録

Aim:The purpose of this study was to evaluate the association between the methylenetetrahydrofolate reductase (MTHFR) C/T polymorphism and the prevalence and course of focal segmental glomerulosclerosis (FSGS) in our pediatric population. Methods: Genotypes for MTHFR were determined in 15 primary FSGS patients (male/female, 6/9) and 238 control subjects (male/female, 110/128) by the polymerase chain reaction and restriction fragment length polymorphism method. Results: For the whole group, the genotype frequencies (CC/CT/TT) of MTHFR in FSGS and control subjects were almost comparable. The TT genotype was associated with early onset of the disease as compared with the CC genotype. Furthermore, all the patients with the TT genotype had steroid-resistant FSGS and developed into end-stage renal failure, while those carrying either CC or CT genotype did not. Conclusion: We speculate that the TT genotype may be associated with early development and progression of childhood FSGS. Confirmatory studies using larger and ethnically distinct populations are needed to reveal the role of homocysteine in FSGS with consideration of medical interventions.

本文言語English
ページ(範囲)449-451
ページ数3
ジャーナルNephron
92
2
DOI
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 腎臓病学
  • 生理学(医学)
  • 泌尿器学

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