Metabolism of chloral hydrate in the anoxic perfused liver

Toshihiro Kawamoto; Tatsuya Hobara; Tatsuya Aoki; Haruo Kobayashi; Susumu Iwamoto; Tsunemi Sakai; Takehito Takano; Yoshifumi Miyazaki; Akihisa Imamura; Keiki Ogino

doi:10.1016/0378-4274(88)90045-8

Metabolism of chloral hydrate in the anoxic perfused liver

Toshihiro Kawamoto, Tatsuya Hobara, Tatsuya Aoki, Haruo Kobayashi, Susumu Iwamoto, Tsunemi Sakai, Takehito Takano, Yoshifumi Miyazaki, Akihisa Imamura, Keiki Ogino

大学院医歯薬学総合研究科

研究成果 › 査読

8 被引用数 (Scopus)

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The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

本文言語	English
ページ（範囲）	225-231
ページ数	7
ジャーナル	Toxicology Letters
巻	40
号	3
DOI	https://doi.org/10.1016/0378-4274(88)90045-8
出版ステータス	Published - 3月 1988

ASJC Scopus subject areas

毒物学

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10.1016/0378-4274(88)90045-8

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title = "Metabolism of chloral hydrate in the anoxic perfused liver",

abstract = "The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.",

keywords = "Anoxia, Chloral hydrate: Trichloroethanol, Drug metabolism, Liver, Perfusion, Trichloroacetic acid",

author = "Toshihiro Kawamoto and Tatsuya Hobara and Tatsuya Aoki and Haruo Kobayashi and Susumu Iwamoto and Tsunemi Sakai and Takehito Takano and Yoshifumi Miyazaki and Akihisa Imamura and Keiki Ogino",

year = "1988",

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doi = "10.1016/0378-4274(88)90045-8",

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T1 - Metabolism of chloral hydrate in the anoxic perfused liver

AU - Kawamoto, Toshihiro

AU - Hobara, Tatsuya

AU - Aoki, Tatsuya

AU - Kobayashi, Haruo

AU - Iwamoto, Susumu

AU - Sakai, Tsunemi

AU - Takano, Takehito

AU - Miyazaki, Yoshifumi

AU - Imamura, Akihisa

AU - Ogino, Keiki

PY - 1988/3

Y1 - 1988/3

N2 - The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

AB - The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

KW - Anoxia

KW - Chloral hydrate: Trichloroethanol

KW - Drug metabolism

KW - Liver

KW - Perfusion

KW - Trichloroacetic acid

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DO - 10.1016/0378-4274(88)90045-8

M3 - Article

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AN - SCOPUS:0023911117

SN - 0378-4274

VL - 40

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EP - 231

JO - Toxicology Letters

JF - Toxicology Letters

IS - 3

ER -

Metabolism of chloral hydrate in the anoxic perfused liver

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