Involvement of iNOS in postischemic heart dysfunction of stroke-prone spontaneously hypertensive rats

Kohji Abe, Miwa Tokumura, Tetsuji Ito, Takashi Murai, Akira Takashima, Nobuhiro Ibii


14 被引用数 (Scopus)


We investigated the possible contribution of inducible nitric oxide synthase (inos) to postischemic heart dysfunction and injuries in stroke-prone spontaneously hypertensive rats (shrsp). Shrsp, 13-14 wk of age, had significantly higher systolic blood pressure and greater heart weight than age-matched Wistar-Kyoto rats (WKY). Permanent occlusion of the left anterior descending coronary artery (LAD) caused significant and long-lasting increases in the activity and mRNA expression of myocardial iNOS in SHRSP compared with WKY. However, there was no significant difference in the LAD occlusion-induced expression of interleukin-1β mRNA between SHRSP and WKY. Hemodynamic deterioration and myocardial fibrosis were also observed in SHRSP at 4 wk after LAD occlusion. Continuous administration of 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT) completely blocked the LAD occlusion-induced increase in the myocardial iNOS activity of SHRSP. Moreover, postischemic heart dysfunction and injuries were also significantly ameliorated by 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT). These results suggest that the increased activity of myocardial iNOS plays a pivotal role in the development of postischemic cardiac dysfunction and injuries in SHRSP with the hypertensive and hypertrophic heart.

ジャーナルAmerican Journal of Physiology - Heart and Circulatory Physiology
2 49-2
出版ステータスPublished - 2月 2001

ASJC Scopus subject areas

  • 生理学
  • 循環器および心血管医学
  • 生理学(医学)


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