Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP)

Toshihide Doi; Tetsuro Sumi; Yukio Nishina; Mitsuko Kosaka; Souichi A. Iwai; Masayoshi Sakuda; Yoshitake Nishimune

doi:10.1016/0304-3835(94)03615-P

Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP)

Toshihide Doi, Tetsuro Sumi, Yukio Nishina, Mitsuko Kosaka, Souichi A. Iwai, Masayoshi Sakuda, Yoshitake Nishimune

研究成果 › 査読

6 被引用数 (Scopus)

抄録

cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.

本文言語	English
ページ（範囲）	81-86
ページ数	6
ジャーナル	Cancer Letters
巻	88
号	1
DOI	https://doi.org/10.1016/0304-3835(94)03615-P
出版ステータス	Published - 1月 6 1995
外部発表	はい

ASJC Scopus subject areas

腫瘍学
癌研究

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1016/0304-3835(94)03615-P

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title = "Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP)",

abstract = "cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.",

keywords = "CDDP, Differentiation, Teratocarcinoma F9 cell",

author = "Toshihide Doi and Tetsuro Sumi and Yukio Nishina and Mitsuko Kosaka and Iwai, {Souichi A.} and Masayoshi Sakuda and Yoshitake Nishimune",

year = "1995",

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doi = "10.1016/0304-3835(94)03615-P",

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T1 - Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP)

AU - Doi, Toshihide

AU - Sumi, Tetsuro

AU - Nishina, Yukio

AU - Kosaka, Mitsuko

AU - Iwai, Souichi A.

AU - Sakuda, Masayoshi

AU - Nishimune, Yoshitake

PY - 1995/1/6

Y1 - 1995/1/6

N2 - cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.

AB - cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.

KW - CDDP

KW - Differentiation

KW - Teratocarcinoma F9 cell

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AN - SCOPUS:0028876650

SN - 0304-3835

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JO - Cancer Letters

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Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP)

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ASJC Scopus subject areas

UN SDG

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