TY - JOUR
T1 - Increased expression of metastasis-associated in colon cancer-1 in renal cell carcinoma is associated with poor prognosis
AU - Jin, Zhong
AU - Xu, Naijin
AU - Guo, Kai
AU - Xu, Peng
AU - Li, Pengju
AU - Zhang, Yiming
AU - Li, Xiezhao
AU - Zheng, Shaobo
AU - Liu, Chunxiao
AU - Xu, Abai
AU - Huang, Peng
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Metastasis-associated in colon cancer-1 (MACC1) expression in tumor specimens is an independent prognostic indicator of metastasis, which has recently gained considerable attention in cancer research, due to its overexpression in several types of carcinoma. However, MACC1 expression patterns and its possible role in renal cell carcinoma remain unknown. This study aimed to investigate MACC1 expression in renal cell carcinoma via immunohistochemical analysis and determine the relationship between MACC1 expression and cancer prognosis. Positive MACC1 expression was found to significantly correlate with distant metastasis and TNM stage (P > 0.05). A Kaplan-Meier survival analysis revealed that patients with higher MACC1 expression had a significantly lower disease-free rate (P > 0.05). These results indicate that MACC1 expression is significantly associated with prognosis in patients with renal cell carcinoma. To the best of our knowledge, this is the first study on the significance of MACC1 as a prognostic marker in renal cell carcinoma. MACC1 expression may be a useful target for the development of new therapeutic approaches, including molecular targeted therapeutic agents, for renal cell carcinoma.
AB - Metastasis-associated in colon cancer-1 (MACC1) expression in tumor specimens is an independent prognostic indicator of metastasis, which has recently gained considerable attention in cancer research, due to its overexpression in several types of carcinoma. However, MACC1 expression patterns and its possible role in renal cell carcinoma remain unknown. This study aimed to investigate MACC1 expression in renal cell carcinoma via immunohistochemical analysis and determine the relationship between MACC1 expression and cancer prognosis. Positive MACC1 expression was found to significantly correlate with distant metastasis and TNM stage (P > 0.05). A Kaplan-Meier survival analysis revealed that patients with higher MACC1 expression had a significantly lower disease-free rate (P > 0.05). These results indicate that MACC1 expression is significantly associated with prognosis in patients with renal cell carcinoma. To the best of our knowledge, this is the first study on the significance of MACC1 as a prognostic marker in renal cell carcinoma. MACC1 expression may be a useful target for the development of new therapeutic approaches, including molecular targeted therapeutic agents, for renal cell carcinoma.
KW - Biomarker
KW - MACC1
KW - Prognosis
KW - Renal cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84935495337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84935495337&partnerID=8YFLogxK
M3 - Article
C2 - 26097569
AN - SCOPUS:84935495337
SN - 1936-2625
VL - 8
SP - 3857
EP - 3863
JO - International Journal of Clinical and Experimental Pathology
JF - International Journal of Clinical and Experimental Pathology
IS - 4
ER -
