In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum

Khurshida Begum, Hye Sook Kim, Veena Kumar, Igor Stojiljkovic, Yusuke Wataya

研究成果査読

38 被引用数 (Scopus)

抄録

The in vitro antimalarial activity against Plasmodium falciparum and heine polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC50) ranging from 15.5 μM to 190 μM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.

本文言語English
ページ(範囲)221-224
ページ数4
ジャーナルParasitology Research
90
3
DOI
出版ステータスPublished - 6月 1 2003

ASJC Scopus subject areas

  • 寄生虫科
  • 獣医学(全般)
  • 昆虫科学
  • 感染症

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