TY - JOUR
T1 - Immunological alterations found in mesothelioma patients and supporting experimental evidence
AU - Miura, Yoshie
AU - Nishimura, Yasumitsu
AU - Maeda, Megumi
AU - Murakami, Shuko
AU - Hayashi, Hiroaki
AU - Fukuoka, Kazuya
AU - Kishimoto, Takumi
AU - Nakano, Takashi
AU - Otsuki, Takemi
N1 - Funding Information:
obtained in the Department of Hygiene, Kawasaki Medical School and published by the authors were supported by Special Coordination Funds for Promoting Science and Technology (H18-1-3-3-1), JSPS KAKENHI (17790375, 18390186, 19689153, 19790431 and 19790411), Kawasaki Medical School Project Grants (16-212, 16-401N, 17-210S, 7-404M, 17-611O, 18-209T, 18-403 and 18-601), a Sumitomo Foundation Grant (053027), and a Yasuda Memorial Foundation Grant (H18).
PY - 2008/3
Y1 - 2008/3
N2 - It is common knowledge that exposure to asbestos causes asbestos-related diseases, such as asbestosis, lung cancer and malignant mesothelioma, not only in people who have had long-term contact with asbestos in their work environment but also in residents living near factories that handle asbestos. Since the summer of 2005, these revelations turned into a large medical problem and caused and social unrest. We have focused on the immunological effects of both asbestos and silica on the human immune system. In this brief review, we introduce immunological alterations found in patients with malignant mesothelioma and describe the experimental background in which these were found. Analyzing the immunological effects of asbestos may improve our understanding of the biological effects of asbestos.
AB - It is common knowledge that exposure to asbestos causes asbestos-related diseases, such as asbestosis, lung cancer and malignant mesothelioma, not only in people who have had long-term contact with asbestos in their work environment but also in residents living near factories that handle asbestos. Since the summer of 2005, these revelations turned into a large medical problem and caused and social unrest. We have focused on the immunological effects of both asbestos and silica on the human immune system. In this brief review, we introduce immunological alterations found in patients with malignant mesothelioma and describe the experimental background in which these were found. Analyzing the immunological effects of asbestos may improve our understanding of the biological effects of asbestos.
KW - Asbestos
KW - Chrysotile
KW - Immunology
KW - Mesothelioma
UR - http://www.scopus.com/inward/record.url?scp=49549085692&partnerID=8YFLogxK
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U2 - 10.1007/s12199-007-0012-y
DO - 10.1007/s12199-007-0012-y
M3 - Article
C2 - 19568881
AN - SCOPUS:49549085692
SN - 1342-078X
VL - 13
SP - 55
EP - 59
JO - Environmental Health and Preventive Medicine
JF - Environmental Health and Preventive Medicine
IS - 2
ER -
