Imaging cardiac neuronal function and dysfunction

Takahiro Higuchi, Markus Schwaiger

研究成果査読

32 被引用数 (Scopus)

抄録

In recent years, the importance of alterations of cardiac autonomic nerve function in the pathophysiology of heart diseases including heart failure, arrhythmia, ischemic heart disease, and diabetes has been increasingly recognized. Several radiolabeled compounds have been synthesized for noninvasive imaging, including single photon emission CT and positron emission tomography (PET). The catecholamine analogue I-123 metaiodoben-zylguanidine (MIBG) is the most commonly used tracer for mapping of myocardial presynaptic sympathetic innervation on a broad clinical basis. In addition, radio-labeled catecholamines and catecholamine analogues are available for PET imaging, which allows absolute quantification and tracer kinetics modeling. Postsynaptic receptor PET imaging added new insights into mechanisms of heart disease. These advanced imaging techniques provide noninvasive, repeatable in vivo information of autonomic nerve function in the human heart and are promising for providing profound insights into molecular pathophysiology, monitoring of treatment, and determination of individual outcome.

本文言語English
ページ(範囲)131-138
ページ数8
ジャーナルCurrent Cardiology Reports
8
2
DOI
出版ステータスPublished - 3月 2006
外部発表はい

ASJC Scopus subject areas

  • 循環器および心血管医学

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