TY - JOUR
T1 - Growth suppression of a cervical cancer cell line (TMCC-1) by the human wild-type p53 gene
AU - Zheng, Peng Sheng
AU - Iwasaka, Tsuyoshi
AU - Ouchida, Mamoru
AU - Fukuda, Koichi
AU - Yokoyama, Masatoshi
AU - Sugimori, Hajime
PY - 1996/2
Y1 - 1996/2
N2 - To investigate the effects of human wild-type p53 expression on the proliferation of cervical carcinoma cells, a plasmid, pMO7-hp53, which contains a full-length cDNA of the human wild-type p53 (wt-p53) gene, was transfected into a cell line (TMCC-1) derived from an endocervical type, human papilloma virus-positive adenocarcinoma of the uterine cervix. The exogenous wt-p53 expression induced growth suppression, morphological changes, and loss of anchorage-independent growth of the tumor cells. As the wt-p53 gene apparently plays a negative role in growth regulation of cervical carcinoma cells, this gene may possibly be of some use for treating subjects with a cervical carcinoma.
AB - To investigate the effects of human wild-type p53 expression on the proliferation of cervical carcinoma cells, a plasmid, pMO7-hp53, which contains a full-length cDNA of the human wild-type p53 (wt-p53) gene, was transfected into a cell line (TMCC-1) derived from an endocervical type, human papilloma virus-positive adenocarcinoma of the uterine cervix. The exogenous wt-p53 expression induced growth suppression, morphological changes, and loss of anchorage-independent growth of the tumor cells. As the wt-p53 gene apparently plays a negative role in growth regulation of cervical carcinoma cells, this gene may possibly be of some use for treating subjects with a cervical carcinoma.
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U2 - 10.1006/gyno.1996.0033
DO - 10.1006/gyno.1996.0033
M3 - Article
C2 - 8631546
AN - SCOPUS:0030028945
SN - 0090-8258
VL - 60
SP - 245
EP - 250
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 2
ER -
