F9 Cells Can be Differentiated toward Two Distinct, Mutually Exclusive Pathways by Retinoic Acid and Sodium Butyrate: teratocarcinoma/differentiation/retinoic acid/sodium butyrate

Mitsuko Kosaka, Masashi Takeda, Keishi Matsumoto, Yoshitake Nishimune

研究成果査読

2 被引用数 (Scopus)

抄録

Both retinoic acid (RA) and sodium butyrate (NaB) induce differentiation in embryonal carcinoma F9 cells. Phenotypic changes caused by RA are irreversible, whereas those of NaB are rapid and reversible. In this study, we investigated the effects of combinations of these two agents on F9 cell differentiation and showed that RA had no effect on the cells induced to differentiate with NaB and vice versa. Thus, F9 cells are induced to differentiate along two distinct pathways which are mutually exclusive.

本文言語English
ページ(範囲)223-230
ページ数8
ジャーナルDevelopment, Growth & Differentiation
36
2
DOI
出版ステータスPublished - 4月 1994
外部発表はい

ASJC Scopus subject areas

  • 発生生物学
  • 細胞生物学

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