TY - JOUR
T1 - Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats
AU - Iwami, Momoe
AU - Mahmoud, Fatma A.
AU - Shiina, Takahiko
AU - Hirayama, Haruko
AU - Shima, Takeshi
AU - Sugita, Jun
AU - Shimizu, Yasutake
N1 - Funding Information:
This work was supported in part by Grants-In-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan .
PY - 2011/4/26
Y1 - 2011/4/26
N2 - Grains of paradise (GP) is a species of the ginger family, Zingiberaceae, extracts of which have a pungent, peppery taste due to an aromatic ketone, 6-paradol. The aim of this study was to explore the thermogenic effects of GP extracts and of 6-paradol. Efferent discharges from sympathetic nerves entering the interscapular brown adipose tissue were recorded. Intragastric injection of a GP extract or 6-paradol enhanced the efferent discharges of the sympathetic nerves in a dose-dependent manner. The enhanced nerve discharges were sustained for as long as 3. h. The rats did not become desensitized to the stimulatory effects these compounds on sympathetic nerve activity. The tissue temperature of brown adipose tissue showed significant increase in rats injected with 6-paradol. These results demonstrate that GP extracts and 6-paradol activate thermogenesis in brown adipose tissue, and may open up new avenues for the regulation of weight loss and weight maintenance.
AB - Grains of paradise (GP) is a species of the ginger family, Zingiberaceae, extracts of which have a pungent, peppery taste due to an aromatic ketone, 6-paradol. The aim of this study was to explore the thermogenic effects of GP extracts and of 6-paradol. Efferent discharges from sympathetic nerves entering the interscapular brown adipose tissue were recorded. Intragastric injection of a GP extract or 6-paradol enhanced the efferent discharges of the sympathetic nerves in a dose-dependent manner. The enhanced nerve discharges were sustained for as long as 3. h. The rats did not become desensitized to the stimulatory effects these compounds on sympathetic nerve activity. The tissue temperature of brown adipose tissue showed significant increase in rats injected with 6-paradol. These results demonstrate that GP extracts and 6-paradol activate thermogenesis in brown adipose tissue, and may open up new avenues for the regulation of weight loss and weight maintenance.
KW - Energy expenditure
KW - Obesity
KW - Pungent compound
KW - Sympathetic nerve
KW - Thermogenic activity
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U2 - 10.1016/j.autneu.2010.11.012
DO - 10.1016/j.autneu.2010.11.012
M3 - Article
C2 - 21185236
AN - SCOPUS:79953752181
SN - 1566-0702
VL - 161
SP - 63
EP - 67
JO - Journal of the Autonomic Nervous System
JF - Journal of the Autonomic Nervous System
IS - 1-2
ER -
