TY - JOUR
T1 - Evolution of pathogenicity controlled by small, dispensable chromosomes in Alternaria alternata pathogens
AU - Tsuge, Takashi
AU - Harimoto, Yoshiaki
AU - Hanada, Kosuke
AU - Akagi, Yasunori
AU - Kodama, Motoichiro
AU - Akimitsu, Kazuya
AU - Yamamoto, Mikihiro
N1 - Funding Information:
Most of this work was supported by Grants-in-Aids for Scientific Research (S) ( 19108001 for TT and 21228001 for KA), Scientific Research (A) ( 23248007 for TT), scientific Research (B) ( 20380028 and 23380025 for MK) and Challenging Exploratory Research ( 15K14662 for TT) from the Japanese Society for Promotion of Sciences and Special Coordination Funds for Promoting Sciences (TT) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan .
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Alternaria alternata includes seven pathogenic variants, called pathotypes, which produce host-selective toxins (HSTs) as determinant factors for pathogenicity. The gene clusters for HST biosynthesis were identified from six pathotypes (Japanese pear, strawberry, tangerine, apple, tomato and rough lemon) and were found to reside on small chromosomes of <2.0 Mb in most strains tested. We isolated mutants lacking the small chromosomes from the strawberry, apple and tomato pathotypes and showed that the small chromosomes are dispensable for growth. In this review, we summarize our current understanding of the evolution of pathogenicity controlled by small, dispensable chromosomes in Alternaria alternata pathogens.
AB - Alternaria alternata includes seven pathogenic variants, called pathotypes, which produce host-selective toxins (HSTs) as determinant factors for pathogenicity. The gene clusters for HST biosynthesis were identified from six pathotypes (Japanese pear, strawberry, tangerine, apple, tomato and rough lemon) and were found to reside on small chromosomes of <2.0 Mb in most strains tested. We isolated mutants lacking the small chromosomes from the strawberry, apple and tomato pathotypes and showed that the small chromosomes are dispensable for growth. In this review, we summarize our current understanding of the evolution of pathogenicity controlled by small, dispensable chromosomes in Alternaria alternata pathogens.
KW - Alternaria alternata
KW - Conditionally dispensable chromosome
KW - Evolution
KW - Host-selective toxin
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U2 - 10.1016/j.pmpp.2016.02.009
DO - 10.1016/j.pmpp.2016.02.009
M3 - Article
AN - SCOPUS:84959922420
SN - 0885-5765
VL - 95
SP - 27
EP - 31
JO - Physiological and Molecular Plant Pathology
JF - Physiological and Molecular Plant Pathology
ER -