TY - JOUR
T1 - Epstein-Barr virus-associated T/natural killer-cell lymphomas in the elderly
T2 - The first consensus meeting in Kofu 2013
AU - Hamada, Toshihisa
AU - Nakamura, Shigeo
AU - Ko, Young Hyeh
AU - Yoshino, Tadashi
AU - Ohshima, Koichi
AU - Matsuzawa, Takamitsu
AU - Miura, Keiko
AU - Takahashi, Toshifumi
AU - Nomura, Hisashi
AU - Hoshino, Tomomi
AU - Suzuki, Daisuke
AU - Shimada, Shinji
AU - Iwatsuki, Keiji
PY - 2014/1
Y1 - 2014/1
N2 - From a clinicopathological conference on nine elderly patients with Epstein-Barr virus (EBV)-associated T/natural killer (NK)-cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. Among these elderly patients (>65 years old), seven patients had extranodal NK/T-cell lymphoma, nasal type (ENKL) with an NK-cell phenotype, and two patients had EBV + T-cell lymphomas or lymphoproliferative disorders (LPD) with cutaneous lesions mimicking pityriasis lichenoides et varioliformis acuta (PLEVA) or hydroa vacciniforme (HV). No patients had a previous episode of EBV-related symptoms such as infectious mononucleosis, chronic active EBV infection, HV or hypersensitivity to mosquito bites. Elderly patients with ENKL may show the centroblastoid variant. EBV+CD8+CD56 +/- lymphocytes may be responsible for the development of PLEVA or HV-like cutaneous lesions in the elderly.
AB - From a clinicopathological conference on nine elderly patients with Epstein-Barr virus (EBV)-associated T/natural killer (NK)-cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. Among these elderly patients (>65 years old), seven patients had extranodal NK/T-cell lymphoma, nasal type (ENKL) with an NK-cell phenotype, and two patients had EBV + T-cell lymphomas or lymphoproliferative disorders (LPD) with cutaneous lesions mimicking pityriasis lichenoides et varioliformis acuta (PLEVA) or hydroa vacciniforme (HV). No patients had a previous episode of EBV-related symptoms such as infectious mononucleosis, chronic active EBV infection, HV or hypersensitivity to mosquito bites. Elderly patients with ENKL may show the centroblastoid variant. EBV+CD8+CD56 +/- lymphocytes may be responsible for the development of PLEVA or HV-like cutaneous lesions in the elderly.
KW - Epstein-Barr virus
KW - T/natural killer-cell lymphoma
KW - centroblastoid
KW - hydroa vacciniforme
KW - nasal type
UR - http://www.scopus.com/inward/record.url?scp=84892682109&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892682109&partnerID=8YFLogxK
U2 - 10.1111/1346-8138.12373
DO - 10.1111/1346-8138.12373
M3 - Article
C2 - 24438143
AN - SCOPUS:84892682109
SN - 0385-2407
VL - 41
SP - 40
EP - 42
JO - Journal of Dermatology
JF - Journal of Dermatology
IS - 1
ER -
