Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

Teruhiko Nitoda; Takahiko Isobe; Isao Kubo

doi:10.1002/ptr.2373

Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

Teruhiko Nitoda, Takahiko Isobe, Isao Kubo

研究成果 › 査読

18 被引用数 (Scopus)

抄録

Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC₅₀ of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.

本文言語	English
ページ（範囲）	867-872
ページ数	6
ジャーナル	Phytotherapy Research
巻	22
号	7
DOI	https://doi.org/10.1002/ptr.2373
出版ステータス	Published - 7月 1 2008
外部発表	はい

ASJC Scopus subject areas

薬理学

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10.1002/ptr.2373

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AB - Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.

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KW - Quercetin

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Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

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