Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats

Maho Dor; Ikuko Miyazaki; Tomoko Nagamachi; Kazuaki Shinomiya; Hisashi Matsunaga; Toshiaki Sendo; Hiromu Kawasaki; Masato Asanuma; Yutaka Gomita; Yoshihisa Kitamura

Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats

Maho Dor, Ikuko Miyazaki, Tomoko Nagamachi, Kazuaki Shinomiya, Hisashi Matsunaga, Toshiaki Sendo, Hiromu Kawasaki, Masato Asanuma, Yutaka Gomita, Yoshihisa Kitamura

研究成果 › 査読

10 被引用数 (Scopus)

抄録

We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.

本文言語	English
ページ（範囲）	219-223
ページ数	5
ジャーナル	Acta medica Okayama
巻	64
号	4
出版ステータス	Published - 8月 2010

ASJC Scopus subject areas

生化学、遺伝学、分子生物学（全般）

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引用スタイル

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title = "Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats",

abstract = "We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.",

keywords = "ACTH, Imipramine, Ki-67, Lithium, Proliferation",

author = "Maho Dor and Ikuko Miyazaki and Tomoko Nagamachi and Kazuaki Shinomiya and Hisashi Matsunaga and Toshiaki Sendo and Hiromu Kawasaki and Masato Asanuma and Yutaka Gomita and Yoshihisa Kitamura",

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T1 - Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats

AU - Dor, Maho

AU - Miyazaki, Ikuko

AU - Nagamachi, Tomoko

AU - Shinomiya, Kazuaki

AU - Matsunaga, Hisashi

AU - Sendo, Toshiaki

AU - Kawasaki, Hiromu

AU - Asanuma, Masato

AU - Gomita, Yutaka

AU - Kitamura, Yoshihisa

PY - 2010/8

Y1 - 2010/8

N2 - We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.

AB - We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.

KW - ACTH

KW - Imipramine

KW - Ki-67

KW - Lithium

KW - Proliferation

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