抄録
This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS). New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 μg to 4 μg, and decreased significantly as the dosage increased from 8 μg to 24 μg. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 μg to 16 μg, and did not significantly change as the dosage increased from 16 μg to 24 μg. These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 481-486 |
| ページ数 | 6 |
| ジャーナル | Dental materials journal |
| 巻 | 26 |
| 号 | 4 |
| DOI | |
| 出版ステータス | Published - 7月 2007 |
ASJC Scopus subject areas
- セラミックおよび複合材料
- 歯科学（全般）