TY - JOUR
T1 - Effect of loratadine on histamine release induced by antigen-antibody reaction
AU - Kamei, Chiaki
AU - Sugimoto, Yukio
AU - Yamaji, Masako
AU - Takada, Miho
PY - 1996/2/21
Y1 - 1996/2/21
N2 - Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.
AB - Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.
KW - Antiallergic drugs
KW - Histamine release
KW - Loratadine
UR - http://www.scopus.com/inward/record.url?scp=0030062599&partnerID=8YFLogxK
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M3 - Article
AN - SCOPUS:0030062599
SN - 0386-3603
VL - 24
SP - 49
EP - 52
JO - Japanese Pharmacology and Therapeutics
JF - Japanese Pharmacology and Therapeutics
IS - 1
ER -