Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils

Feng Lu; Takehiro Nakamura; Tetsuhiko Toyoshima; Yanan Liu; Kazuyuki Hirooka; Nobuyuki Kawai; Naohiko Okabe; Fumio Shiraga; Takashi Tamiya; Osamu Miyamoto; Richard F. Keep; Toshifumi Itano

doi:10.1016/j.neulet.2011.10.041

Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils

Feng Lu, Takehiro Nakamura, Tetsuhiko Toyoshima, Yanan Liu, Kazuyuki Hirooka, Nobuyuki Kawai, Naohiko Okabe, Fumio Shiraga, Takashi Tamiya, Osamu Miyamoto, Richard F. Keep, Toshifumi Itano

大学院医歯薬学総合研究科

研究成果 › 査読

19 被引用数 (Scopus)

抄録

The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3. mg/kg; i.p.) 30. min before transient forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5. min. The effects of edaravone were examined by measuring neuronal damage and behavioral deficits. Hexanoyl-lysine adduct (HEL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were also examined to assess the anti-oxidative effects of edaravone. Edaravone treatment significantly inhibited both lipid and DNA oxidative damage 72. h after ischemia, and decreased neuronal damage. Edaravone also significantly reduced the locomotor activity deficit 72. h after ischemia and improved memory impairment. These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits.

本文言語	English
ページ（範囲）	28-32
ページ数	5
ジャーナル	Neuroscience Letters
巻	506
号	1
DOI	https://doi.org/10.1016/j.neulet.2011.10.041
出版ステータス	Published - 1月 6 2012

ASJC Scopus subject areas

神経科学（全般）

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10.1016/j.neulet.2011.10.041

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引用スタイル

Lu, F., Nakamura, T., Toyoshima, T., Liu, Y., Hirooka, K., Kawai, N., Okabe, N., Shiraga, F., Tamiya, T., Miyamoto, O., Keep, R. F., & Itano, T. (2012). Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils. Neuroscience Letters, 506(1), 28-32. https://doi.org/10.1016/j.neulet.2011.10.041

Lu, F, Nakamura, T, Toyoshima, T, Liu, Y, Hirooka, K, Kawai, N, Okabe, N, Shiraga, F, Tamiya, T, Miyamoto, O, Keep, RF & Itano, T 2012, 'Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils', Neuroscience Letters, vol. 506, no. 1, pp. 28-32. https://doi.org/10.1016/j.neulet.2011.10.041

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abstract = "The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3. mg/kg; i.p.) 30. min before transient forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5. min. The effects of edaravone were examined by measuring neuronal damage and behavioral deficits. Hexanoyl-lysine adduct (HEL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were also examined to assess the anti-oxidative effects of edaravone. Edaravone treatment significantly inhibited both lipid and DNA oxidative damage 72. h after ischemia, and decreased neuronal damage. Edaravone also significantly reduced the locomotor activity deficit 72. h after ischemia and improved memory impairment. These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits.",

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AU - Itano, Toshifumi

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N2 - The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3. mg/kg; i.p.) 30. min before transient forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5. min. The effects of edaravone were examined by measuring neuronal damage and behavioral deficits. Hexanoyl-lysine adduct (HEL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were also examined to assess the anti-oxidative effects of edaravone. Edaravone treatment significantly inhibited both lipid and DNA oxidative damage 72. h after ischemia, and decreased neuronal damage. Edaravone also significantly reduced the locomotor activity deficit 72. h after ischemia and improved memory impairment. These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits.

AB - The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3. mg/kg; i.p.) 30. min before transient forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5. min. The effects of edaravone were examined by measuring neuronal damage and behavioral deficits. Hexanoyl-lysine adduct (HEL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were also examined to assess the anti-oxidative effects of edaravone. Edaravone treatment significantly inhibited both lipid and DNA oxidative damage 72. h after ischemia, and decreased neuronal damage. Edaravone also significantly reduced the locomotor activity deficit 72. h after ischemia and improved memory impairment. These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits.

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