Facile addition of primary alkyl Gridnard reagents to vinylsilanes has been realized for the first time by exploiting the directing effect of a 2-pridyl group on silicon [Eq. (1)]. Three-component coupling reactions of a Grignard reagent, the vinylsilane, and an electrophile, followed by oxidative removal of the 2-pyridyldimethylsilyl group with H2O2 furnishes various secondary alcohols in excellent overall yields.
|ジャーナル||Angewandte Chemie - International Edition|
|出版ステータス||Published - 6月 18 2001|
ASJC Scopus subject areas
- 化学 (全般)