Directed intermolecular carbomagnesation across vinylsilanes: 2-PyMe₂Si group as a removable directing group

Facile addition of primary alkyl Gridnard reagents to vinylsilanes has been realized for the first time by exploiting the directing effect of a 2-pridyl group on silicon [Eq. (1)]. Three-component coupling reactions of a Grignard reagent, the vinylsilane, and an electrophile, followed by oxidative removal of the 2-pyridyldimethylsilyl group with H₂O₂ furnishes various secondary alcohols in excellent overall yields.