抄録
Eleven cases of Hodgkin's disease (HD) were examined for the presence of the Epstein‐Barr virus (EBV) genome, using the polymerase chain reaction (PCR) to detect EBV DNA in whole paraffin‐embedded tissue specimens and in single cells picked out from the specimens with a micromanipulator. The EBV genome was detected in 5 of the 11 cases by conventional PCR. Single cell PCR demonstrated the EBV genome in Reed‐Sternberg cells from all the EBV‐positive cases, but not from any of the EBV‐negative cases. Background lymphocytes and lysozyme‐positive histiocytes from EBV‐positive cases did not contain the EBV genome. These results indicate an etiological association of EBV with some cases of HD.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 329-333 |
| ページ数 | 5 |
| ジャーナル | Japanese Journal of Cancer Research |
| 巻 | 83 |
| 号 | 4 |
| DOI | |
| 出版ステータス | Published - 4月 1992 |
ASJC Scopus subject areas
- 腫瘍学
- 癌研究
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
