TY - JOUR
T1 - Constituents of Psoralea corylifolia fruits and their effects on methicillin-resistant Staphylococcus aureus
AU - Cui, Yanmei
AU - Taniguchi, Shoko
AU - Kuroda, Teruo
AU - Hatano, Tsutomu
N1 - Publisher Copyright:
© 2015 by the authors; licensee MDPI.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%-16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.
AB - Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%-16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.
KW - Bakuflavanone
KW - Bakuisoflavone
KW - Methicillin-resistant staphylococcus aureus
KW - Psoralea corylifolia
UR - http://www.scopus.com/inward/record.url?scp=84938344604&partnerID=8YFLogxK
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U2 - 10.3390/molecules200712500
DO - 10.3390/molecules200712500
M3 - Article
C2 - 26184136
AN - SCOPUS:84938344604
SN - 1420-3049
VL - 20
SP - 12500
EP - 12511
JO - Molecules
JF - Molecules
IS - 7
ER -