@article{1852058a313240e984c37dc5600cab7d,
title = "Concise synthesis of anticancer active trans-4-(4-Octylphenyl)prolinol",
abstract = "Concise synthesis of anticancer active trans-4-(4-octylphenyl)prolinol has been achieved. Regioselective iodination of aromatic compound and subsequent Suzuki-Miyaura cross-coupling with trans-1-octen-1-ylboronic acid produced the desired coupling product. Further transformation of this product afforded trans-4-(4-octylphenyl)prolinol. The synthesis of this anticancer compound has been performed with 23% overall yield and six steps, which have been improved in comparison with those (3.5% overall yield and eight steps) previously reported.",
author = "Junki Ando and Aoi Tazawa and Kohei Ishizawa and Minoru Tanaka and Hiroyoshi Takamura",
note = "Funding Information: We thank Dr. Masayuki Watanabe, Mr. Kazunari Shimooka, and Ms. Kaoru Marukawa for valuable discussions. We also thank Ms. Kaori Murakoshi for technical support of LC-MS/MS analysis, Ms. Saori Tahara for technical support of IR analysis, and Mr. Iwao Takamuro for helpful advice. This research was supported by Mitsubishi Tanabe Pharma Corporation. Publisher Copyright: {\textcopyright} 2019 The Japan Institute of Heterocyclic Chemistry.",
year = "2019",
doi = "10.3987/COM-18-S(F)44",
language = "English",
volume = "99",
pages = "716--723",
journal = "Heterocycles",
issn = "0385-5414",
publisher = "Japan Institute of Heterocyclic Chemistry",
number = "1",
}