@article{2017195a68ea41d3b1915859a62ea53e,
title = "Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide",
abstract = "Graphene oxide (GO) is one of the most studied nanomaterials in many fields, including the biomedical field. Most of the nanomaterials developed for drug delivery and phototherapies are based on noncovalent approaches that lead to an unspecific release of physisorbed molecules in complex biological environments. Therefore, preparing covalently functionalized GO using straightforward and versatile methods is highly valuable. Phototherapies, including photothermal therapy (PTT) and photodynamic therapy (PDT), have shown great potential as effective therapeutic approaches against cancer. To overcome the limits of a single method, the combination of PTT and PDT can lead to a combined effect with a higher therapeutic efficiency. In this work, we prepare a folic acid (FA) and chlorin e6 (Ce6) double-functionalized GO for combined targeted PTT/PDT. This conjugate can penetrate rapidly into cancer cells and macrophages. A combined effect of PTT and PDT is observed, leading to a higher killing efficiency toward different types of cells involved in cancer and other diseases. Our work provides a simple protocol to prepare multifunctional platforms for the treatment of various diseases.",
keywords = "Carbon nanomaterials, chlorin e6, macrophages, phototherapy, targeting",
author = "Shi Guo and Zhengmei Song and Ji, {Ding Kun} and Giacomo Reina and Fauny, {Jean Daniel} and Yuta Nishina and C{\'e}cilia M{\'e}nard-Moyon and Alberto Bianco",
note = "Funding Information: Funding: This work was partly supported by the Agence Nationale de la Recherche (ANR) through the LabEx project Chemistry of Complex Systems (ANR-10-LABX-0026_CSC). We wish to acknowledge the support of the Centre National de la Recherche Scientifique (CNRS) through the International Research Project MULTIDIM between I2CT Unit and Okayama University and the International Center for Frontier Research in Chemistry (icFRC). The authors gratefully acknowledge the financial support from the Shanghai Sailing Program (20YF1424500). Funding Information: This work was partly supported by the Agence Nationale de la Recherche (ANR) through the LabEx project Chemistry of Complex Systems (ANR-10-LABX-0026_CSC). We wish to acknowledge the support of the Centre National de la Recherche Scientifique (CNRS) through the International Research Project MULTIDIM between I2CT Unit and Okayama University and the International Center for Frontier Research in Chemistry (icFRC). The authors gratefully acknowledge the financial support from the Shanghai Sailing Program (20YF1424500). The authors wish to thank C. Royer at the “Plateforme Imagerie In Vitro de l{\textquoteright}ITI Neurostra”, CNRS UAR 3156, University of Strasbourg, France) for her help with TEM analyses and H. Dali for her help with cell culture. S. Guo is indebted to the Chinese Scholarship Council for supporting his Ph.D internship. Funding Information: Acknowledgments: The authors wish to thank C. Royer at the “Plateforme Imagerie In Vitro de l{\textquoteright}ITI Neurostra”, CNRS UAR 3156, University of Strasbourg, France) for her help with TEM analyses and H. Dali for her help with cell culture. S. Guo is indebted to the Chinese Scholarship Council for supporting his Ph.D internship. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = jul,
doi = "10.3390/pharmaceutics14071365",
language = "English",
volume = "14",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",
}
