@article{079eaee20cd24d5f85e7391f864850c8,
title = "Chemical synthesis and antifouling activity of monoterpene-furan hybrid molecules",
abstract = "Geraniol, a monoterpene, and furan are structural motifs that exhibit antifouling activity. In this study, monoterpene-furan hybrid molecules with potentially enhanced antifouling activity were designed and synthesized. The nine synthetic hybrids showed antifouling activity against the cypris larvae of the barnacle Balanus (Amphibalanus) amphitrite with EC50 values of 1.65-4.70 μg mL−1. This activity is higher than that of geraniol and the reference furan compound. This hybridization approach to increase antifouling activity is useful and can also be extended to other active structural units.",
author = "Hiroyoshi Takamura and Yuya Kinoshita and Takefumi Yorisue and Isao Kadota",
note = "Funding Information: We are grateful to Dr Noriyuki Endo (Himeji EcoTech Co., Ltd.) for valuable discussions and Mr Kosuke Hattori (Okayama University), Mr Yuji Sugita (Okayama University), and Ms. Shiori Kitade (University of Hyogo) for experimental support. We appreciate the Division of Instrumental Analysis at Okayama University for assistance with the NMR and HRMS measurements. This work was supported by the Iketani Science and Technology Foundation, the Fukuoka Naohiko Memorial Foundation, and the JSPS via KAKENHI grant JP21H01938. Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",
year = "2022",
doi = "10.1039/d2ob02203f",
language = "English",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
}