Changes in Polyamine Metabolism of Rat Liver After Administration of D-Galactosamine: Favorable Effects of Putrescine Administration on Galactosamine-Induced Hepatic Injury

Yasushi Daikuhara, Fumihiko Tamada, Masaharu Takigawa, Yoshiro Takeda, Yoichi Mori

研究成果査読

29 被引用数 (Scopus)

抄録

There are many reports showing a close relation between polyamine metabolism and tissue growth or recovery of damaged tissues, such as regenerating liver. Thus, changes in polyamine metabolism in the livers from rats treated with D-galactosamine, an inducer of experimental hepatitis, were studied. The activity of ornithine decarboxylase started to increase 14 hr after administration of galactosamine and reached 30 times the normal activity at about 25 hr, the time of maximum severity of hepatitis. The content of putrescine increased to about 10 times the control value. After increases in the putrescine content and ornithine decarboxylase activity, the hepatitis started to diminish. Increases in the activity of S-adenosylmethionine decarboxylase and the content of spermidine were observed 33-37 hr after administration of galactosamine. The maximum values of these parameters, which were significantly higher than the control values, were observed after the healing process had started. Administration of putrescine to rats given galactosamine significantly decreased the severity of acute hepatitis, as judged by the activities of serum transaminases and hepatic glucose-6-phosphate dehydrogenase and by histologic findings. Other diamines, such as cadaverine or 1,3-diaminopropone, did not affect the levels of serum transaminases, but administration of spermidine to rats reduced the high levels of serum transaminases induced by golactosamine.

本文言語English
ページ(範囲)123-132
ページ数10
ジャーナルGastroenterology
77
1
DOI
出版ステータスPublished - 1979
外部発表はい

ASJC Scopus subject areas

  • 肝臓学
  • 消化器病学

フィンガープリント

「Changes in Polyamine Metabolism of Rat Liver After Administration of D-Galactosamine: Favorable Effects of Putrescine Administration on Galactosamine-Induced Hepatic Injury」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル