Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy

Nozomi Hishikawa, Yoshio Hashizume, Masaaki Hirayama, Kazuhiro Imamura, Yukihiko Washimi, Yasuo Koike, Chiyuki Mabuchi, Mari Yoshida, Gen Sobue

研究成果査読

27 被引用数 (Scopus)

抄録

The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was not apparent. Numerous Lewy bodies were widely evident microscopically in brainstem nuclei and the intermediolateral cell columns of the spinal cord, as well as in the sympathetic ganglia, but were rare or absent in the cerebral cortex and other supratentorial structures. Marked neuronal loss was seen in the locus ceruleus, raphe nuclei, dorsal vagal nuclei, and intermediolateral cell columns, but neurons in the substantia nigra, other brain regions, and sympathetic ganglia appeared undiminished. This case represents a specific clinicopathologic form of Lewy body disease occurring predominantly in the brainstem, spinal cord, and sympathetic ganglia.

本文言語English
ページ(範囲)139-143
ページ数5
ジャーナルClinical Autonomic Research
10
3
DOI
出版ステータスPublished - 2000
外部発表はい

ASJC Scopus subject areas

  • 内分泌系および自律システム
  • 臨床神経学

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