Biodegradable chitosan-silicate porous hybrids for drug delivery

Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka

研究成果査読

11 被引用数 (Scopus)

抄録

Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3- glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.

本文言語English
ページ(範囲)1219-1222
ページ数4
ジャーナルKey Engineering Materials
361-363 II
出版ステータスPublished - 1月 1 2008

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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