Attenuation of the phosphatidylinositol 3-Kinase/Akt signaling pathway by porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp

Masaaki Nakayama; Tetsuyoshi Inoue; Mariko Naito; Koji Nakayama; Naoya Ohara

doi:10.1074/jbc.M114.591610

Attenuation of the phosphatidylinositol 3-Kinase/Akt signaling pathway by porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp

Masaaki Nakayama, Tetsuyoshi Inoue, Mariko Naito, Koji Nakayama, Naoya Ohara

研究成果 › 査読

43 被引用数 (Scopus)

抄録

Background: The significance of gingipains on the PI3K/Akt signaling pathway is poorly understood.Results: The inactivation of PI3K and Akt was induced by P. gingivalis, which was associated with gingipains.Conclusion: Gingipains are critical for suppressing the PI3K/Akt signaling pathway via extracellular proteolysis independent of P. gingivalis invasion. Significance: This study shows the first evidence that the gingipains negatively regulate the PI3K/Akt signaling pathway.

本文言語	English
ページ（範囲）	5190-5202
ページ数	13
ジャーナル	Journal of Biological Chemistry
巻	290
号	8
DOI	https://doi.org/10.1074/jbc.M114.591610
出版ステータス	Published - 2月 20 2015

ASJC Scopus subject areas

生化学
分子生物学
細胞生物学

文献へのアクセス

10.1074/jbc.M114.591610

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引用スタイル

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abstract = "Background: The significance of gingipains on the PI3K/Akt signaling pathway is poorly understood.Results: The inactivation of PI3K and Akt was induced by P. gingivalis, which was associated with gingipains.Conclusion: Gingipains are critical for suppressing the PI3K/Akt signaling pathway via extracellular proteolysis independent of P. gingivalis invasion. Significance: This study shows the first evidence that the gingipains negatively regulate the PI3K/Akt signaling pathway.",

author = "Masaaki Nakayama and Tetsuyoshi Inoue and Mariko Naito and Koji Nakayama and Naoya Ohara",

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AU - Naito, Mariko

AU - Nakayama, Koji

AU - Ohara, Naoya

PY - 2015/2/20

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AB - Background: The significance of gingipains on the PI3K/Akt signaling pathway is poorly understood.Results: The inactivation of PI3K and Akt was induced by P. gingivalis, which was associated with gingipains.Conclusion: Gingipains are critical for suppressing the PI3K/Akt signaling pathway via extracellular proteolysis independent of P. gingivalis invasion. Significance: This study shows the first evidence that the gingipains negatively regulate the PI3K/Akt signaling pathway.

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